Searching for Engrams
نویسندگان
چکیده
منابع مشابه
Searching for Engrams
Recent advances in cellular imaging technologies together with novel genetic tools have enabled the observation of minute anatomical changes in the intact brain. This has elevated the search for physical correlates of memory, one of the longstanding questions in modern neurobiology, to a new level. Utilizing these new tools, several studies have recently been published pointing to subcellular s...
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Memories are the experiential threads that tie our past to the present. The biological realization of a memory is termed an engram-the enduring biochemical and physiological processes that enable learning and retrieval. The past decade has witnessed an explosion of engram research that suggests we are closing in on boundary conditions for what qualifies as the physical manifestation of memory. ...
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Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown. We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear me...
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ژورنال
عنوان ژورنال: Neuron
سال: 2010
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2010.06.033